Application Overview

Moisture and organic vapours can affect the solid state. This may be due to the formation of a hydrate phase or an induced amorphous-to-crystalline phase transition. These moisture-induced phase changes can affect mechanical properties, cause chemical interactions and alter yield, purity and dosage calculations.

The IGAsorp uses the GVS technique (Gravimetric Vapour Sorption, also known as Dynamic Vapour Sorption or Dynamic Moisture Sorption) and is designed to characterise sorption isotherms, investigate hydrate phases and deliquescence, detect and quantify amorphous phases and measure kinetics such as diffusion rates and Moisture Vapour Transmission Rates (MVTR’s).

Our instruments are the preferred vapour sorption instruments in many leading laboratories worldwide and references can be provided on request.

Advantages of our instruments include:

• Designed and manufactured to ISO-9001 quality standards
• 21 CFR part 11 compliant software
• High resolution mode with steps of less than 1% RH for hydrate studies
• Unique IGA method for faster analysis times without compromising accuracy

Please use our enquiry form to request any of these application notes.

References

[1] Effect of Salt Type on Hygroscopicity of a New Cephalosporin S-3578
Kohsaku Kawakami, Yasuo Ida and Tohru Yamaguchi
Pharmaceutical Research 22 (8) (2005) 1365 – 1373

[2] Crystallization of Sucrose Glass under ambient conditions: Evaluation of Crystallization Rate and unusual Melting Behavior of Resultant Crystals
Kohsaku Kawakami, Kyoko Miyoshi, Naomi Tamura, Tohru Yamaguchi, Yasuo Ida
Journal of Pharmaceutical Sciences 95, (6) (2006) 1354-1363